djr-1.2 Antibody

Code CSB-PA586390XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans djr-1.2 Polyclonal antibody
Uniprot No.
Target Names
djr-1.2
Alternative Names
djr-1.2 antibody; C49G7.11Glutathione-independent glyoxalase DJR-1.2 antibody; EC 4.2.1.130 antibody; Protein DJ-1 homolog 2 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans djr-1.2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Catalyzes the conversion of methylglyoxal (MG) or glyoxal (GO) to D-lactate or glycolic acid respectively in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against glyoxal-induced cell death. Protects dopaminergic neurons from glyoxal-dependent neuronal degeneration.
Gene References into Functions
  1. These data demonstrate a novel role for the DJ-1 homologue, djr-1.2, in mitigating Manganese-dependent lifespan reduction and dopamine signaling alterations. PMID: 25531510
  2. Expression of DJR-1.2 is highly increased in the dauer stage. PMID: 23624124
  3. Sub-lethal doses of glyoxals caused significant degeneration of the dopaminergic neurons in C. elegans lacking cDJR-1.2. PMID: 22523093
Subcellular Location
Cytoplasm.
Protein Families
Peptidase C56 family, DJ-1 subfamily
Tissue Specificity
Expressed in various tissues, including pharyngeal muscles, pharynx-intestinal valve, ventral nerve cord, spermatheca, rectal gland, inner labial (IL) cells of head neurons, phasmid (PHA/PHB) neurons in tail and supporting sheath/socket cells, as well as
Database Links

KEGG: cel:CELE_C49G7.11

STRING: 6239.C49G7.11

UniGene: Cel.4466

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