Nop60B Antibody

Datasheet

Code	CSB-PA006919XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Nop60B Polyclonal antibody

Uniprot No.

O44081

Target Names

Nop60B

Alternative Names

Nop60B antibody; mfl antibody; CG3333 antibody; H/ACA ribonucleoprotein complex subunit 4 antibody; EC 5.4.99.- antibody; Nucleolar protein AT band 60B antibody; Protein minifly antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Nop60B protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. Required for maintenance of the germline stem cell lineage during spermatogenesis.

Gene References into Functions

Study demonstrates that either ubiquitous or escargot-driven dyskerin depletion specifically abolishes the formation of the intestinal imaginal islands, the transient stem cell niche, without any apparent effect on the other midgut cell types. PMID: 28337032
Pseudouridine synthase (diskerin,Mfl)depletion also causes disruption of adherens cell junctions and ectopic induction of JNK (c-Jun N-terminal kinase) and Mmp1 (matrix metalloproteinase-1) activity, leading to a significant epithelial reorganization PMID: 25811802
Mutations in Nop60B, the Drosophila homolog of human dyskeratosis congenita 1, affect the maintenance of the germ-line stem cell lineage during spermatogenesis. PMID: 12645924
results expand repertoire of coding/non-coding transcripts derived from the gene encoding Drosophila pseudouridine synthase It exhibits complex interlaced organization. PMID: 17328797

Subcellular Location

Nucleus, nucleolus.

Protein Families

Pseudouridine synthase TruB family

Database Links

KEGG: dme:Dmel_CG3333

STRING: 7227.FBpp0099583

UniGene: Dm.1944

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Nop60B Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background