Product Details

Full Product Name

Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) dlc Polyclonal antibody

Uniprot No.

Q9IAT6

Target Names

dlc

Alternative Names

dlcDelta-like protein C antibody; DeltaC antibody; delC antibody

Raised in

Rabbit

Species Reactivity

Danio rerio (Zebrafish) (Brachydanio rerio)

Immunogen

Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) dlc protein

Immunogen Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized.

Gene References into Functions

Fgfr4 mediates a signal-transduction pathway between Wnt16 and Dlc, but not Dld, to regulate haematopoietic stem cells specification. PMID: 25428693
Ablation of xanthophores in yellow stripes induced melanophore death in black stripes, suggesting that melanophores require a survival signal from distant xanthophores. DeltaC and notch1a were expressed by xanthophores and melanophores, respectively. PMID: 24306107
DeltaC and DeltaD interact as Notch ligands in the zebrafish segmentation clock. PMID: 21653612
Data show that deltaC is required for coherence of wavelike expression domains of cyclic genes her1 and her7 and maintenance of their expression levels, as well as for cyclic transcription of deltaC itself. PMID: 15766754
Expression of deltaC oscillates in the presomitic mesoderm; analysis of its oscillation in relation to that of other oscillating genes in the PSM reveals differences in subcellular localization of the oscillating mRNAs in individual cells PMID: 16125692
In zebrafish embryos oscillations of adjacent cells are synchronized and amplified by deltaC in the posterior presomitic mesoderm as cell movement subsides and cells maintain stable neighbour relationships. PMID: 17417625
Notch signalling via DeltaC keeps the oscillations of neighbouring cells in synchrony. PMID: 17535112
Data show that two deltaC splice-variants have distinct signaling abilities during somitogenesis and midline patterning. PMID: 18430417

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Strongly expressed in the early retina, where it precedes other delta proteins. Also expressed in cranial ganglia, in sensory epithelia including ear and lateral line and in scattered epidermal cells. In the mesoderm, expression is visible by 50% epiboly;

Database Links

KEGG: dre:30120

STRING: 7955.ENSDARP00000018643

UniGene: Dr.81314

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dlc Antibody

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