dam Antibody

Datasheet

Code	CSB-PA360101XA01ENV
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Escherichia coli (strain K12) dam Polyclonal antibody

Uniprot No.

P0AEE8

Target Names

dam

Alternative Names

dam antibody; b3387 antibody; JW3350DNA adenine methylase antibody; EC 2.1.1.72 antibody; DNA adenine methyltransferase antibody; Deoxyadenosyl-methyltransferase antibody; M.EcoDam antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli (strain K12)

Immunogen

Recombinant Escherichia coli (strain K12) dam protein

Immunogen Species

Escherichia coli (strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function

Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication.

Gene References into Functions

Structural analysis of a new Dam binding site on DNA with implications for methylation-independent transcriptional repression. PMID: 25845600
We propose a model for intrasite methylation in which Dam bound to flanking DNA is an obligate intermediate. PMID: 22570478
structural and functional analysis PMID: 15456775
the up-regulation of recombinational repair in dam mutants allows for the efficient repair of double-strand breaks whose formation is dependent on functional mismatch repair PMID: 16199573
DNA regions accessible to Dam methylase in transfected human cells apparently coincided with those hypersensitive to DNase I. PMID: 16897455
Lys(14) is important for EcoDam binding of the extrahelical target base into the active site pocket PMID: 17545164
only at low Lrp concentrations will Dam compete effectively for binding and methylation of the proximal GATC site, leading to a phase switch resulting in the expression of pili PMID: 18706913
Unlike other restriction-modification methyltransferases, E. coli DNA adenine methyltransferase carries out intrasite processive catalysis whereby the enzyme-DNA complex methylates both strands of unmethylated GATC site prior to dissociation from DNA. PMID: 19580332

Hide All

Protein Families

N(4)/N(6)-methyltransferase family

Database Links

KEGG: ecj:JW3350

STRING: 316385.ECDH10B_3562

Promotions

Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

TWIK2 channel mediates inflammation, study finds Protein Acetylation: An Important Post-translational Modification in Eukaryotic Cells Neuronal Markers and Neurodegenerative Diseases Claudin 18.2, is a 'Dark Horse' in Anti-tumour Therapy? What Are Histones: Unraveling Their Critical Roles in Disease Pathogenesis Melanoma, the Most Serious Type of Skin Cancer Information You Must Know about KCNN4 Streptococcus pneumoniae, a Primary Cause of Pneumonia The True Face of Tumor Suppressor Gene p53 EGFR and Its Application in Cancer Therapy An Overview of Cell Death: Necrosis and Apoptosis The Overview of One Category of Important Cell Receptors: Receptor Tyrosine Kinases TNFRSF9: A Potent Immune-Stimulator in Cancer TNFR1: A Multifaceted Molecule in Cancer, Another Promising Therapeutic Target for COVID-19 NRG1: an Intriguing Therapeutic Target in Diseases Approaches to Determinate Protein Concentration C5AR1: A Potential Molecule of Complement System to Fuel COVID-19 Therapy! Lysosomal Enzymes and Lysosomal Storage Disorders (LSDs) Cellular Senescence and Its Markers NKG2D, a Powerful Molecule Involved In CAR-T And Car-NK Cell Therapy DLL3: A New Molecular Target in Cancer Does LIF Only Play a Role in Leukaemia? DNA Damage and Repair TFPI: a Natural Anticoagulant Protein, Future Therapies for Hemophilia DT3C, a Powerful Tool for ADC Drug Internalization In Vitro Proteolysis Targeting Chimera (PROTAC): A CLDN6: A "New Favorite" in Targeted Cancer Therapy after CLDN 18.2! Intestinal Mucosal Barrier Bodyguard --ALPi GPRC5D: Newly Efficient GPRC5D CAR-T or Bispecific Antibody Therapy to Fight Multiple Myeloma (MM) The Collection of Progress of Anti-GPCR Antibody Drugs CD31- A Complex Function Molecule CD14, A Membrane Receptor for Bacterial Lipopolysaccharides ERBB3/HER3: a New Target for Tumor Therapy, a Driver Gene of Multi-Tumors How Do You Get Exosomes? CD73, What a Powerful Therapy Target in Tumor Immune CAR-T Cell Therapy- An Useful Treatment To Cancer Exploring Biological Landscape of Cervical Cancer: A Comprehensive Overview for Researchers CLDN4: A Potential Prognostic Indicator and Therapeutic Target in Tumors！ What Are the Best Methods for Protein Purification? A Practical Guide TFR1 (TFRC): a Stimulator of Fe Transport Affects Anemia, Neurodegenerative Disorders and Cancers! Categories over 10000! --Rare diseases that are no longer Protein Phosphorylation: The Dynamic Language of Cellular Regulation Differentiation of Th17 Cells Microglial Markers: Insights into Microglial Activation and Function Knowledge about Transthyretin Homeobox Transcription Factor- NANOG DSG2: a Vital Member of Desmosomal Cadherin Family, an Exciting New Target for Cardiomyopathy, Adenovirus, and Tumors! Glial Fibrillary Acidic Protein - Astrocyte Specific Marker MYL9: a New Member of Myosin Motors, a Key Driver of Cancer Cell Dynamic Regulation? ZG16B: A New Tumor Biomarker Offers Important Insights for Drug Development in Pancreatic Cancer! Anti-Payload Antibody DXD: A Highly Potent Tool for ADCs Pharmacokinetic (PK) Analysis! Interleukin 4 receptor (IL-4R/IL-4Ra): a Multifunctional Target of Cytokines, Suggesting Diverse Potential in Asthma, Rhinitis, Viral, and Tumor Research! Leukemia, Why is it So Common? The Overview of Cell Viability Bladder Cancer: Insights into Molecular Biology,Signaling Pathways, and Biomarkers The Metabolic Phenotype of Tumor-Associated Macrophages in the Tumor Microenvironment Stem Cell-What a Miraculous Resource in Human Body IL-6-Do You Really Know That? Growth Hormone - Not Only Promotes Height Increase What Do You Need to Know Before Researching Human Metapneumovirus? One World, One Hope——What Can We Do about AIDS? What You Have to Know about Cytokine Storm and Virus Infection Toll-like Receptors--The Eye of Innate Immunity A Comprehensive Exploration into Amyotrophic Lateral Sclerosis CD46, A Complement Regulator ACVRL1 (Alk1): a Member of the TGF-β Receptor Family, a Novel Target for Anti-Angiogenic Drug Research! A "trembling" Parkinson's Disease Focus on Emerging Therapeutic Targets BCMA Hematopoietic Stem Cell Surface Marker CD20 Monoclonal Antibodies Drugs: There is an Explosion of New mAbs Against CD20! The Overview of Coagulation Understanding of Serum Albumin What You Have To Know about Lung Cancer TMEFF2: a Tumor-Specific Methylated Biomarker, a Novel Target in Multiple Cancers Protein Kinases Overview: Definition, Types, Function, Activation Mechanism, etc. The Overview of Hippo Signaling Pathway Exploring Neurodegeneration: A Comprehensive Guide for Researchers Tools You Need For Fundamental Research CD22- What A Powerful Co-receptor of B Cell Receptor Epigenetic Histone Modifications Pathway Unraveling the Dynamic World of Histone Modifications: Implications in Gene Regulation and Disease Pathogenesis CD48: An Emerging Human Immune Co-stimulatory Molecule, Friend or Foe? The Multifunctional Enzyme CD38: A Target for Immunotherapeutic Approaches in Cancer What Essential Biological Knowledge is Needed for Hepatocellular Carcinoma Research? What Are the Effects of Abnormalities in the ALK Gene CD146, A Powerful Tumor Marker GPCR Drugs Discovery Introduction of Hepatocellular Carcinoma Related Signaling Pathways SIGIRR: A Novel Member of the TIR Superfamily Acts as the Anti-Inflammatory 'Brake' to Control Immune Response in Various Diseases! Mesothelin: A Rising Star of Cancer Immunotherapy ACE2, The Hottest Target of SARS-CoV-2 Invasion PD-1-- An Important Immune Checkpoint Tetraspanin CD81: a Key Receptor for Hepatitis C Virus (HCV), an Established Exosome Marker, a Promising Target for Antiviral or Antitumor Research! CRTAM: Class I Restricted T cell-associated Molecule, an Intriguing New Member of the Ig-SF Family! TMPRSS2, an Activator for SARS-CoV-2 Invasion An Overview of CD226 and Its Promising Role in Cancer Immunotherapy TROP2, An Important Target for Cancer Research OMA1-A Potential Cancer Therapy Target TASIN represents a promising approach for prevention of colorectal cancer Exploring the Science of Influenza A Virus: What You Need to Know Mucin-17/MUC17: An Unexpected Target for Tumor Immune Therapy, Notably Gastric Cancer! ANGPT2 (Ang-2): the First Bispecific Antibody for Eye Vision Loss Therapy, a Novel Target for Tumor Angiogenesis! The Overview of Chemokine Norwalk Virus IL-17A: A Major Cytokine of the IL-17 Family, a Key Inflammation Target in Skin Diseases, or Inflammation-Associated Cancers! Serotransferrin/TF: a Major Transferrin in Plasma, a Novel TF-Modified Nanoparticle for Tumor-Targeting Research! FAP may be a drug target for pancreatic cancer The Overview of Colony Stimulating Factors Do You Really Know Neurons and Glia Cells in Nerve System? Apoptosis mediated by mitochondria Apoptosis mediated by endoplasmic reticulum Inhibition of ASCT2 combats cancer in vitro and in vivo Aesthetic Appreciation of Apoptosis Signal Pathway CD69: a Classical Early Marker of Lymphocyte Activation, a Pivotal Regulator of Hematologic Diseases and Autoimmune Disorders! EphA3-A Regulator of Cell Adhesion and Migration Itaconate is a negative regulator of inflammation The Memory thief - Alzheimer's disease Tumor Necrosis Factor (TNF) The Overview of Interferon Tumor markers A Group of Promising Proteins - Cell Cycle Markers The Overview of Interleukin The Overview of Organelles The Overview of Autophagy How to Choose an Antibody for Scientific Research? Production of Recombinant Protein Crosstalk Between Autophagy and Apoptosis TTR: an Important Protein of Amyloidosis, Novel Therapies are Upcoming for Rare Diseases ATTR-CM and ATTR-PN! CDCP1: A Key Mediator for Cell Signaling in Cancers, an Emerging Target for Anti-Tumor Drugs! Double-Edged Sword: TGF-β Chemokine Receptor CCR6: the Specific Receptor for CCL20, a Potential Target for Drug Research in Inflammatory Diseases and Gastrointestinal Cancer! What Is Tomato Mosaic Virus IL2RA (CD25): A Specific Marker of Tregs Functions as Both Immune Modulators and Targeted Agents in Various Diseases! What Should You Know about Exosomes? The Review of Post-translational Modifications CXCR4: An Attractive Target of GPCR family Brings Promising New Drugs for Cancer Therapy！ CLDN3: Another Tight Junction Protein or New Drug Target, Interest in CLDN Family is Growing Fast! ENPP3 (CD203c): An Extracellular Enzyme, a Regulator for Nucleotide and Energy, an Indicator for Allergies, an Effective Target for RCC Therapy! GUCY2C: a Novel Target in Tumor Immunotherapy, Specially in Colorectal Cancer CAR T Therapy! Oncostatin M (OSM): A Member of IL-6 Cytokine Family, An Underestimated Player in Future Targeted Therapies? CNR1 (CB1): A Crucial Receptor of Endocannabinoid System Offers Potential Treatments for Tumors and Glycolipid Metabolism Disorders! MAGEA4: a Member of the Melanoma-Associated Antigen (MAGE) Family, a Popular Target for Tumor-Specific Immune Research! In Vivo vs. In Vitro: Choosing the Right Experimental Model for Your Research Dipeptidase 3 (DPEP3): an Emerging Member of the DPEP Family, a Potential Therapeutic Target in Male Fertility or Tumor Research! Exploring Protein-Protein Interactions: A Comprehensive Guide to Understanding and Utilizing It IL-6: an Important Participant in the Inflammatory Cascade, One of the Most Functional Cytokines in Various Diseases Research! Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

Join us with

Subscribe newsletter

Leave a message

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

dam Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background