Dys Antibody

1. Dys protein regulates tarsal joint formation in response to Notch activity during Drosophila leg development. PMID: 25329825
2. The findings suggest that the signaling functions of Dystrophin protein are able to ameliorate dilated cardiomyopathy, and thus might help to improve heart muscle function in micro-Dystrophin-based gene therapy approaches. PMID: 24231130
3. 3 5' promoters and 3 internal promoters regulate expression of 3 full-length and 3 truncated products, respectively. The existence of this complex gene structure in such evolutionary remote organisms suggests that it has diverse important functions PMID: 16198353
4. Lack of the large dystrophin isoforms in the postsynaptic muscle cell leads to elevated evoked neurotransmitter release from presynaptic terminals. PMID: 16399704
5. Our results indicate the existence of at least two possibly separate roles of dystrophin in muscle, maintaining synaptic homeostasis and preserving the structural stability of the muscle. PMID: 17543506
6. The det locus encodes Drosophila dys, which acts with other components of the DAPC to influence intercellular signalling in developing wing veins. PMID: 18093579
7. RNAi-mediated knockdown in the mesoderm shortens lifespan. Deletion of the large isoforms increases the heart rate by widening the cardiac tube and lowering fractional shortening, a phenotype reminiscent of dilated cardiomyopathy PMID: 18221418
8. Possibility that Dp186 modulates other non-Gbb/Wit-dependent retrograde signaling pathways required to maintain normal synaptic physiology. PMID: 18463264

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UniGene: Dm.16710