DND1 Antibody

Datasheet
Code CSB-PA757815XA01MO
Product Type Polyclonal Antibody
Uniprot No. Q6VY05
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Mus musculus (Mouse) DND1 protein
Raised in Rabbit
Species Reactivity Mus musculus (Mouse)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Dead end protein homolog 1 (RNA-binding motif, single-stranded-interacting protein 4) Dnd1 Rbms4 Ter
Immunogen Species Mus musculus (Mouse)
Gene Names Dnd1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression (By similarity). Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs (By similarity). Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs (By similarity). Does not bind to miRNAs (By similarity). Isoform 1 may play a role during primordial germ cell (PGC) survival. However, does not seem to be essential for PGC migration.
Involvement in disease Defects in Dnd1 are the cause of the Ter mutation phenotype. Ter mice are characterized by primordial germ cell loss and susceptibility to spontaneous testicular germ cell tumors (TGCT). They are sterile, but viable. Isoform 1 defects may be the cause of tumor development.
Subcellular Location Nucleus, Cytoplasm
Tissue Specificity Isoform 1 and isoform 2 are expressed in testis. Isoform 1 is expressed continuously in post natal (PN) testis although levels are low between PN1 to PN6. Isoform 2 is expressed from PN 20 onwards. Isoform 2 is strongly expressed in meiotic and in post-me
Database Links

KEGG: mmu:213236

STRING: 10090.ENSMUSP00000054412

UniGene: Mm.234464

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