dom Antibody

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Code	CSB-PA889043XA01DLU
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Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) dom Polyclonal antibody

Uniprot No.

Q9NDJ2

Target Names

dom

Alternative Names

dom antibody; CG9696Helicase domino antibody; EC 3.6.4.- antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) dom protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in Notch signaling. Represses E2F target genes. Required for somatic stem cell self-renewal but not for germline stem cell self-renewal. Involved in oogenesis.

Gene References into Functions

Dom acts pleiotropically as a positive effector of Notch signaling and a repressor of proliferation. PMID: 23550128
DOM is implicated in developmental gene activation PMID: 16024792

Subcellular Location

Nucleus.

Protein Families

SNF2/RAD54 helicase family, SWR1 subfamily

Tissue Specificity

Isoform B is present at high levels in ovary, in follicle cells, nurse cells and oocyte. Isoform B is also present in germline and somatic stem cells from the germarium. Isoform A is undetectable in adult ovary (at protein level).

Database Links

KEGG: dme:Dmel_CG9696

STRING: 7227.FBpp0071529

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dom Antibody

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