dnaE Antibody

1. results support a model in which the pol and exo activities of pol III core are effectively independent, and in which recognition of the 3' end of the primer by either alpha or epsilon is governed by the primer stability. PMID: 28263430
2. Mutation in PHP domain of Pol III alpha ablated interaction with the proofreading subunit. PMID: 25987558
3. Data show that the tau (tau), alpha (alpha), epsilon (epsilon), and theta (theta;) subunits of DNA Polymerase III can be assembled in vivo, yielding the trimeric tau3alpha3epsilon3theta;3 complex. PMID: 25918025
4. The results suggest that competition between UmuD and ssDNA for DNA polymerase III alpha binding is a new mechanism for polymerase exchange. PMID: 23901012
5. The PHP domain is a major structural element in Pol III and its integrity modulates both the stability and activity of the polymerase. PMID: 23672456
6. Authors demonstrate for the first time that the major DNA polymerases (Pol I and Pol III) and DNA ligase are directly involved with oligo recombination. PMID: 23634873
7. A structural model of the alphaepsilontheta;:beta2 replicase complex reveals a compact, but still flexible, structure of the complex. PMID: 23580545
8. Authors report that DNA pol III incorporates 8-oxo-dGTP approximately 20 times more efficiently opposite template A compared with template C. PMID: 23043439
9. Authors propose that the interaction between DNA polymerase III alpha and UmuD contributes to the transition between replicative and translesion synthesis polymerases by removing DNA polymerase III alpha from the beta clamp. PMID: 22406830
10. Here we show that, in contrast to distributive DNA synthesis exhibited by wild-type alpha subunit, the dnaE173 mutant form of alpha subunit catalyzes highly processive DNA chain elongation without the aid of the beta-clamp PMID: 17895578
11. Data shows that the proofreading domain of epsilon subunit is connected to alpha via a flexible linker peptide comprising over 20 residues. PMID: 18663010

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KEGG: ecj:JW0179

STRING: 316385.ECDH10B_0164