tam Antibody

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Code	CSB-PA630644XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) tam Polyclonal antibody

Uniprot No.

Q27607

Target Names

tam

Alternative Names

tam antibody; DNApol-gamma antibody; DNApol-gamma125 antibody; DNApolG1 antibody; l(2)34Dc antibody; l(2)br5 antibody; MtPolA antibody; pol antibody; gamma-alpha antibody; Polg antibody; CG8987DNA polymerase subunit gamma-1 antibody; mitochondrial antibody; EC 2.7.7.7 antibody; 3'-5' exodeoxyribonuclease antibody; EC 3.1.11.- antibody; Mitochondrial DNA polymerase catalytic subunit antibody; Protein tamas antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) tam protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

As the catalytic component of the DNA polymerase gamma complex is involved in the replication of mitochondrial DNA (mtDNA). Has both 5'-3' DNA polymerase and a highly mispair-specific 3'-5' exonuclease activity. At the end of mtDNA replication DNA ends are ligated to produce a closed circular mtDNA molecule, its exonuclease activity is required for formation of these ligatable ends by preventing DNA synthesis from continuing past the 5'-end of downstream DNA into duplex DNA regions. Does not possess DNA primase activity, does not catalyze strand displacement synthesis and does not contain a 5'-3' exonuclease activity to catalyze nick translation. Important for promoting the elimination of paternal mitochondrial DNA during spermatogenesis, however its exact role in this function has not yet been identified and appears to be independent of its 3'-5'-exonuclease activity and only partially dependent on its DNA polymerase activity.

Gene References into Functions

Knockdown of the nuclear-encoded mtDNA polymerase, Tamas, produces a more complete block of mtDNA elimination. PMID: 28318978
Muscle-specific overexpression of the catalytic subunit of DNA polymerase gamma induces pupal lethality in Drosophila melanogaster. PMID: 23729397
DNA-binding mutants of mitochondrial single-stranded DNA-binding protein are defective in stimulation of DNA synthesis by pol gamma PMID: 14754882

Subcellular Location

Mitochondrion.

Protein Families

DNA polymerase type-A family

Database Links

KEGG: dme:Dmel_CG8987

STRING: 7227.FBpp0080148

UniGene: Dm.2292

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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tam Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background