dpy-27 Antibody

Code CSB-PA342976XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans dpy-27 Polyclonal antibody
Uniprot No.
Target Names
dpy-27
Alternative Names
dpy-27 antibody; R13G10.1Chromosome condensation protein dpy-27 antibody; Protein dumpy-27 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans dpy-27 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Central component of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription throughout development. Its strong similarity with the condensin subunit smc4 suggests that it may reduce the X-chromosome transcript level by condensing the chromatin structure during interphase. Involved in the recruitment of the dosage compensation proteins mix-1 and dpy-21 to the X chromosome. Might be involved in the reduction of histone H4 lysine 16 acetylation (H4K16ac) on dosage compensated X chromosomes. As a member of the dosage compensation complex, also binds to regulatory regions of the autosomal her-1 gene, required for male development, possibly contributing to its repression in hermaphrodites. Also plays a role in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway.
Gene References into Functions
  1. Findings identify a Structural Maintenance of Chromosomes (SMC)-like protein, SMCL-1 (C44C10.4), that binds to condensin subunits dpy-26, dpy-27 and dpy-28 and modulates condensin functions. PMID: 28301465
Subcellular Location
Nucleus. Chromosome.
Protein Families
SMC family, SMC4 subfamily
Database Links

KEGG: cel:CELE_R13G10.1

STRING: 6239.R13G10.1

UniGene: Cel.7349

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