retn Antibody

Code CSB-PA635529XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) retn Polyclonal antibody
Uniprot No.
Target Names
retn
Alternative Names
retn antibody; dri antibody; CG5403Protein dead ringer antibody; Protein retained antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) retn protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcription factor which is a downstream target of gcm and repo. Directly or indirectly activates the transcription of locos and pros, which are essential for the development of some glial cells. Plays an essential role in defining the cell shape and migration characteristics of longitudinal glia that enable them to establish a normal axon scaffold.
Gene References into Functions
  1. Dead ringer's preference for AT-rich DNA originates from three positions within the ARID fold that form energetically significant contacts to an adenine-thymine base step. PMID: 11867548
  2. RETN has a role in Drosophila preblastoderm syncytial mitoses PMID: 12141428
  3. Data suggest that Drosphila dead ringer is an important regulator of the late development of longitudinal glia. PMID: 12620977
  4. retained/dead ringer is necessary for neuronal pathfinding, female receptivity and repression of fruitless independent male courtship behaviors PMID: 15576402
Subcellular Location
Nucleus.
Tissue Specificity
Present in the pharyngeal muscles, hindgut epithelium, amnioserosa, ring gland, midgut-hindgut junction, posterior region of each brain lobe, longitudinal glial cells of the CNS and the salivary gland duct of germ-band retracted embryos.
Database Links

KEGG: dme:Dmel_CG5403

STRING: 7227.FBpp0071982

UniGene: Dm.20640

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