Drice Antibody

Code CSB-PA519033XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Drice Polyclonal antibody
Uniprot No.
Target Names
Drice
Alternative Names
Drice antibody; ICE antibody; CG7788Caspase antibody; EC 3.4.22.- antibody; drICE) [Cleaved into: Caspase subunit p21; Caspase subunit p12] antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Drice protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro.
Gene References into Functions
  1. Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila. PMID: 26542461
  2. drICE plays an important role in activating corpse clearance in dying cells, and that an additional function of effector caspases is required for the activation of corpse clearance as well as that for carrying out cell death. PMID: 26022392
  3. Both autophagy and caspase activity are induced by 20-hydroxyecdysone during the larval-prepupal transition. PMID: 24036278
  4. The caspase effector DRICE is activated during apoptosis in both mid- and late oogenesis; however, active DRICE was found more ubiquitously and at a higher level during germline cell death in midoogenesis. PMID: 12885559
  5. examination of inhibition by DIAP1 PMID: 15107838
  6. Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells. PMID: 15657059
  7. The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process PMID: 16887831
  8. Ice is essential for induction of apoptosis in S2 cells. PMID: 17341581
  9. The conjugation of ubiquitin to ice suppresses its catalytic potential in cleaving caspase substrates. PMID: 19026784

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Protein Families
Peptidase C14A family
Database Links

KEGG: dme:Dmel_CG7788

STRING: 7227.FBpp0084848

UniGene: Dm.2333

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