DRM2 Antibody

1. CHH methylation in the egg cell depends on DOMAINS REARRANGED METHYLASE 2 (DRM2) and RNA polymerase V (Pol V), two main actors of RNA-directed DNA methylation, but does not depend on Pol IV PMID: 28115468
2. DRM2 gene expression throughout normal development in Arabidopsis PMID: 25842863
3. Study shows that Arabidopsis DRM2 exists in complex with the small interfering RNA (siRNA) effector ARGONAUTE4 (AGO4) and preferentially methylates one DNA strand, likely the strand acting as the template for RNA polymerase V-mediated noncoding RNA transcripts. PMID: 24855943
4. These findings substantiate the view that DRM2 is the major de novo DNA methyltransferase in the RdDM pathway and support a direct catalytic role for this enzyme in RdDM. PMID: 21212233
5. Data show that by site-directed mutagenesis that both the DRM2 N-terminal UBA domains and C-terminal methyltransferase domain are required for normal RNA-directed DNA methylation, supporting an essential targeting function for the UBA domains. PMID: 21060858
6. JMJ14 is specifically involved in the maintenance phase of DRM2-mediated RNA-directed DNA methylation. PMID: 21052090
7. SRA-domain proteins ( suvh9 and suvh2 ) required for DRM2-mediated de novo DNA methylation PMID: 19043555

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KEGG: ath:AT5G14620

STRING: 3702.AT5G14620.1

UniGene: At.5084