DSK2 Antibody

1. functional yeast proteasomes have the capacity to associate and dissociate with Rpn10 and that Rpn10 monoubiquitination decreases the Rpn10-proteasome and Rpn10-Dsk2 associations. PMID: 26450923
2. C-terminal UBA domain of Dsk2 ubiquitin receptor protects it by preventing initiation of protein degradation at the proteasome. PMID: 21304520
3. These results indicate that ubiquitination in the UBL domain of Dsk2 has in vivo functions in the ubiquitin-proteasome pathway in yeast. PMID: 21763274
4. Data describe formation of ternary complexes of Dsk2 and Rpn10 with (poly)ubiquitin and found that, depending on the ubiquitin chain length, the orientation of the resulting complex is entirely different, providing for alternate signals. PMID: 20064467
5. Using a genome-wide functional screen, we have identified 11 yeast genes that cause slower growth upon their overexpression in cells lacking two ubiquitin-binding proteins Rad23 and Dsk2. PMID: 19909498
6. structure reveals that the UBA domain uses a mode of ubiquitin recognition that is similar to that of the CUE domain, another ubiquitin binding motif that shares low sequence homology but high structural similarity with UBA domains PMID: 15837191
7. These results suggest that Dsk2 homodimerization via the UBA domain plays a role in regulating polyubiquitin binding in the ubiquitin-proteasome pathway. PMID: 16140271

Show More

Hide All

KEGG: sce:YMR276W

STRING: 4932.YMR276W