DTL Antibody

Datasheet
Code CSB-PA725479XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q5RHI5
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) DTL protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Denticleless protein homolog dtl cdt2 si:dkey-18c8.4
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names dtl
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination
Subcellular Location Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Chromosome
Protein Families WD repeat cdt2 family
Database Links

KEGG: dre:192314

STRING: 7955.ENSDARP00000033992

UniGene: Dr.3526

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