dyb-1 Antibody

Code CSB-PA897452XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans dyb-1 Polyclonal antibody
Uniprot No.
Target Names
dyb-1
Alternative Names
dyb-1 antibody; F47G6.1 antibody; Dystrobrevin-1 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans dyb-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance.
Gene References into Functions
  1. SLO-1 potassium channels distinctively form organized clusters at presynaptic terminals; two cytoskeletal proteins, CTN-1 and DYB-1, are crucial for normal SLO-1 cluster formation PMID: 25907097
  2. the interaction between alpha-catulin and alpha-dystrobrevin is evolutionarily conserved in C. elegans and mouse muscles and strongly suggests that this interaction contributes to the integrity of the dystrophin complex PMID: 22577143
  3. These observations revealed novel functions of dystrobrevin in controlling neurotransmitter release and muscle Ca(2+) transients by localizing the BK channel. PMID: 22131396
Subcellular Location
Cytoplasm.
Protein Families
Dystrophin family, Dystrobrevin subfamily
Tissue Specificity
From late embryogenesis to adulthood, expressed in neurons and muscles; particularly strong in the ventral nerve cord and in muscles of the body wall, head pharyngeal, and vulva; weaker in the intestinal muscle (at protein level).
Database Links

KEGG: cel:CELE_F47G6.1

STRING: 6239.F47G6.1

UniGene: Cel.19602

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