dhc-1 Antibody

1. Data indicate a role for DHC-1, the dynein heavy chain, in maintaining neuronal cargo distribution. PMID: 28406181
2. Dynein tethered to the cell cortex generates pulling forces that position the mitotic spindle. Two distinct cortical dynein populations together create a robust force-generating system in the polarized one-cell Caenorhabditis elegans embryo. PMID: 28739679
3. we dissect the role of dynactin's microtubule binding activity, located in the p150 CAP-Gly domain and an adjacent basic patch, in the C. elegans zygote. Our results suggest that p150 GAP-Gly domain binding to microtubules promotes initiation of dynein-mediated organelle transport in the dividing one-cell embryo, and that this function of p150 is critical for generating cytoplasmic pulling forces for centrosome PMID: 28759579
4. Mutations affecting dhc-1 and cyb-3 cooperate to increase fitness in the absence of MDF-1. PMID: 25486568
5. Data present evidence that bicd-1 operates in a conserved pathway with dhc-1 and unc-116. PMID: 21205795
6. Dhc-1, as well as the dynactin components dnc-1 (p150Glued) and dnc-2 (p50/dynamitin), are essential for LIS-1 targeting to the nuclear periphery. PMID: 15331665
7. mutational analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans PMID: 15616192
8. Data show that accumulation of dynein at poles was kinesin-1 independent and APC dependent, just like dynein driven spindle movements. PMID: 19357192

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KEGG: cel:CELE_T21E12.4

STRING: 6239.T21E12.4

UniGene: Cel.19011