DYN1 Antibody

1. Interplay among dynein, dynactin, and the stability of the microtubule substrate creates a mechanism that regulates accurate spindle positioning. PMID: 28572117
2. Lis1 (Pac1) regulates dynein by sterically blocking its mechanochemical cycle. PMID: 25380312
3. DYN1 is engaged in bidirectional helical motility around microtubules in the process of cargo transport. PMID: 25069614
4. Study reports X-ray and electron microscopy structures of yeast dynein, DYN1 bound to different ATP analogs, which collectively provide insight into the roles of dynein's two major ATPase sites, AAA1 and AAA3, in the conformational change mechanism. PMID: 25417161
5. The authors find that dynein has a highly variable stepping pattern that is distinct from all other processive cytoskeletal motors, which use 'hand-over-hand' mechanisms. PMID: 22231401
6. study presents a 6 angstrom crystal structure of a functional dimer of two ~300-kilodalton motor domains of cytoplasmic dynein PMID: 21330489
7. A model for how dynein's two motor domains coordinate their activities during normal processive motility. PMID: 18045537
8. the nucleotide binding state at AAA3 and AAA4 of the heavy chain of cytoplasmic dynein can allosterically modulate microtubule binding affinity and affect dynein processivity and force production PMID: 18650442
9. Results suggest that dynein and Cin8 cooperate in anaphase midzone organization and influence microtubule dynamics, thus enabling progression through the slow phase of anaphase B. PMID: 19099194

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KEGG: sce:YKR054C

STRING: 4932.YKR054C