Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) DYN2 Polyclonal antibody

Uniprot No.

Q02647

Target Names

DYN2

Alternative Names

DYN2 antibody; SLC1 antibody; YDR424CDynein light chain 1 antibody; cytoplasmic antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) DYN2 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Also a component of the nuclear pore complex where it may contribute to the stable association of the Nup82 subcomplex with the NPC.

Gene References into Functions

Both, Pex14p and Pex17p interact directly with Dyn2p, but in vivo, Pex17p turned out to be prerequisite for an association of Dyn2p with Pex14p. PMID: 27823812
interactions of a yeast ortholog of N-IC (N-Pac11) with yeast LC8 (Dyn2) or with the intermediate chain-binding subunit of yeast dynactin (Nip100). PMID: 26253171
The Dyn2-Pac11 complex promotes Dyn1 homodimerization and potentiates processivity. PMID: 23761070
Multiple recognition motifs in nucleoporin Nup159 provide a stable and rigid Nup159-Dyn2 assembly PMID: 23223634
Data indicate that the comparative binding of Dyn2 to two Nup159 target sites shows similar affinities (18 and 13 muM), but divergent thermal binding modes. PMID: 22411995
Dynein-based function of Dyn2 is via its interaction with the dynein intermeadite chains; this interaction is also important for the interaction of dynein and dynactin. PMID: 21633107
Dynein light chain plays a role in organizing natively unfolded Phe-Gly repeats within the NPC scaffold to facilitate nucleocytoplasmic transport PMID: 17546040

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Subcellular Location

Cytoplasm, cytoskeleton. Nucleus, nuclear pore complex.

Protein Families

Dynein light chain family

Database Links

KEGG: sce:YDR424C

STRING: 4932.YDR424C

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DYN2 Antibody

Product Details

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Target Background