Cdlc2 Antibody

Code CSB-PA528535XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Cdlc2 Polyclonal antibody
Uniprot No.
Target Names
Cdlc2
Alternative Names
Cdlc2 antibody; CG5450Dynein light chain 2 antibody; cytoplasmic antibody; 8 kDa dynein light chain antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Cdlc2 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Acts as a non-catalytic accessory component of a dynein complex.
Gene References into Functions
  1. Results show assembled dynein IC as an elongated, flexible polybivalent duplex, and suggest that polybivalency is an important general mechanism for constructing stable yet reversible and functionally versatile complexes. PMID: 19759397
  2. The induced folding of cytoplasmic dynein intermediate chain IC(1-289) upon LC8 light chain binding suggests that LC8 could act through the intermediate chain to facilitate dynein assembly or regulate cargo-binding interactions. PMID: 15581372
  3. We propose that Msn functions together with Bic-D to regulate the apical localization of dynein in generating directed nuclear migration within differentiating R-cell precursor cells. PMID: 15582780
  4. Dynein light chain 1 regulates dynamin-mediated F-actin assembly during sperm individualization in Drosophila PMID: 15829565
  5. dynein-dynactin, abnormal spindle protein (Asp), and KLP10A have roles in Drosophila spindle pole organization PMID: 15888542
  6. Dynein-mediated transport of specific RNAs along specialized networks of microtubules increases the efficiency of their delivery, over the flow of general cytoplasmic components, into the oocyte PMID: 17442699

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Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
Dynein light chain family
Database Links

KEGG: dme:Dmel_CG5450

STRING: 7227.FBpp0077590

UniGene: Dm.1988

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