Defb4 Antibody

Code CSB-PA305482ZA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Defb4 Polyclonal antibody
Uniprot No.
Target Names
Defb4
Alternative Names
Defb4 antibody; Bdef4Beta-defensin 4 antibody; BD-4 antibody; mBD-4 antibody; Defensin antibody; beta 4 antibody
Raised in
Rabbit
Species Reactivity
Mus musculus
Immunogen
Recombinant Mus musculus Defb4 protein
Immunogen Species
Mus musculus (Mouse)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to mouse (but not human) CCR6 and induce chemotactic activity of CCR6-expressing cells.
Gene References into Functions
  1. The time course of MBD-4 levels in plasma of trauma mice has a similar trend to the HBD-2 levels in plasma of multiple injured patients. MBD-4 expression is induced in liver tissue after multiple trauma. PMID: 28270138
  2. beta-defensin 4 and 14 contribute to the innate and adaptive immune response in their role as chemoattractants PMID: 20483750
  3. Data show that recombinant mBD4:Ig and hBD2:Ig fusion proteins retained potent antimicrobial activity against Gram-negative and Gram-positive bacteria, and that these fusion proteins showed specific binding to CCR6-expressing cells. PMID: 20068036
  4. Murine beta-defensins-1 and -4 were present in newborn skin PMID: 12612195
Subcellular Location
Secreted.
Protein Families
Beta-defensin family
Tissue Specificity
Tongue, esophagus and trachea.
Database Links

KEGG: mmu:56519

UniGene: Mm.45276

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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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