E2AK3 Antibody

Code CSB-PA889055XA01DLU
Size Pls inquire
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Product Details

Full Product Name Rabbit anti-Drosophila melanogaster (Fruit fly) PEK Polyclonal antibody
Uniprot No. Q9NIV1
Target Names PEK
Alternative Names PEK antibody; EIF2AK3 antibody; CG2087Eukaryotic translation initiation factor 2-alpha kinase antibody; EC 2.7.11.1 antibody; PRKR-like endoplasmic reticulum kinase antibody; DmPEK antibody; PEK antibody; PERK antibody
Raised in Rabbit
Species Reactivity Drosophila melanogaster (Fruit fly)
Immunogen Recombinant Drosophila melanogaster (Fruit fly) E2AK3 protein
Immunogen Species Drosophila melanogaster (Fruit fly)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

Function
(From Uniprot)
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis.
Gene References into Functions
  1. PERK and GCN2 act on FOXO to potentiate FOXO activity which has been implicated in the development and progression of a variety of diseases. PMID: 30043468
  2. We show that the PKR-like ER kinase (PERK) integrates both cell-autonomous and non-autonomous endoplasmic reticulum stress stimuli to induce intestinal stem cell proliferation. PMID: 25945494
Subcellular Location Endoplasmic reticulum membrane, Single-pass type I membrane protein
Protein Families Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily
Database Links

KEGG: dme:Dmel_CG2087

STRING: 7227.FBpp0078417

UniGene: Dm.3303

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