egl-1 Antibody

1. LIN-1 binds to, and activates transcription of, the key pro-apoptotic gene egl-1. Our results provide the first evidence that EGF induces PCD at the whole organism level and reveal the molecular basis for the death-promoting function of LIN-3/EGF PMID: 25144461
2. The transcriptional upregulation of egl-1 in the CEMs in hermaphrodites is necessary, but not sufficient for their death. PMID: 20150917
3. DNA damage increases expression of the proapoptotic gene egl-1, a response that requires hus-1 and the p53 homolog cep-1 PMID: 12445383
4. the binding of EGL-1 to CED-9 is extremely stable PMID: 12894216
5. Metabolism of mutants of the proapoptotic EGL-1 protein was studied in a functional analysis of the CED-1 protein. PMID: 15383288
6. mitochondria fragment in cells that normally undergo programmed cell death during C. elegans development; fragmentation is induced by the BH3-only protein EGL-1 PMID: 15716954
7. A complex between MAB-5 and the Pbx homolog CEH-20 directly regulates transcription of the BH3 domain gene egl-1 to initiate programmed cell death PMID: 16421192
8. Consistent with its ability to neutralize CED-9 function, EGL-1 antagonized CED-9-dependent remodeling of the mitochondrial network. PMID: 16543146
9. oxidative, osmotic, heat shock and starvation stresses induce germ cell apoptosis through a p53 and EGL-1 independent pathway. PMID: 16729024
10. Data show that the worm protein EGL-1 binds mammalian pro-survival proteins very poorly, but can be converted into a high-affinity ligand for Bcl-2 and Bcl-x(L) by mutation of the cysteine residue at position 62 within the BH3 domain. PMID: 18566606
11. Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans. PMID: 19327994
12. EGL-1 triggers apoptosis induction predominantly by antagonizing the function of an anti-apoptotic member of the core BCL-2 family. Review. PMID: 19641505

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KEGG: cel:CELE_F23B12.9

STRING: 6239.F23B12.9

UniGene: Cel.19641