Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans egl-15 Polyclonal antibody

Uniprot No.

Q10656

Target Names

egl-15

Alternative Names

egl-15 antibody; F58A3.2Myoblast growth factor receptor egl-15 antibody; EC 2.7.10.1 antibody; Egg-laying defective protein 15 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans egl-15 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Receptor tyrosine kinase required for larval development. May phosphorylate adapter protein soc-1 which in turn may result in the recruitment and/or activation of phosphatase ptp-2. May activate the Ras/MAPK kinase signaling pathway which includes sem-5, sos-1, let-60/Ras, lin-45/Raf, mek-2 and mpk-1. Acts in the hypodermis to regulate axon growth and fluid homeostasis. Activates protein degradation in muscles. Probably following interaction with ligand let-756, regulates negatively membrane protrusion from body wall muscles during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine. Regulates synaptic levels of nAChR subunit lev-1 in the nerve cord.; Affects the maintenance of axon position without affecting axon growth. Interaction with egl-17 is required for the guidance of sex myoblast migration during gonad development.; Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.; Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.; Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.; Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.

Gene References into Functions

Study identified the mechanism that maintains presynaptic distribution during postdevelopmental growth; the requirement of a SLC17 family transporter CIMA-1. CIMA-1 antagonizes a specific FGFR isoform, EGL-15(5A), in epidermal cells to modulate glial morphology, in turn modulating AIY synaptic distribution.[ PMID: 23870123
Intestinal tube formation in Caenorhabditis elegans requires egl-15 signaling PMID: 20004187
Results show that N-glycans negatively regulate EGL-15 FGFR activity in vivo supporting the notion that mutation of N-glycosylation sites in human FGFR may lead to inappropriate activation of the receptor. PMID: 19801543
report the identification of a novel EGL-15 receptor isoform that is generated by alternate splicing; present evidence that the two different forms of EGL-15 are responsible for its two distinct functions PMID: 12835392
Reporters for egl-15 exons 5A and 5B showed tissue-specific profiles, and we isolated mutants defective in the tissue specificity. PMID: 17060915
EGL-15(5A) is predominantly expressed in the M lineage, which gives rise to the migrating sex myoblasts and their sex muscle descendants, while EGL-15(5B) is predominantly expressed in the hypodermis. PMID: 18455716

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily

Database Links

KEGG: cel:CELE_F58A3.2

STRING: 6239.F58A3.2c

UniGene: Cel.17140

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egl-15 Antibody

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