egl-5 Antibody

Code CSB-PA324634XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans egl-5 Polyclonal antibody
Uniprot No.
Target Names
egl-5
Alternative Names
egl-5 antibody; ceh-11 antibody; C08C3.1Homeobox protein egl-5 antibody; Egg-laying defective protein 5 antibody; Homeobox protein ceh-11 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans egl-5 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Essential for the determination of specific neurons.
Gene References into Functions
  1. EGL-5 is required for subtype-specific circuit formation in both sensory neurons and interneurons. PMID: 26539892
  2. egl-5 plays an instructive role in male cell fate determination in the C. elegans somatic gonad. PMID: 20553900
  3. Data present an analysis of cis-regulatory elements in the Caenorhabditis elegans Hox gene egl-5, which is expressed in multiple tissues in the posterior region of the nematode. PMID: 15581880
  4. Mutating a CCAAT box in the proximal promoter of egl-5 leads to the derepression of egl-5, suggesting a direct role for the NFY complex in the regulation of egl-5. PMID: 17574230
  5. Expression of EGL-5 in the HSN motor neuron/PHB sensory neuron precursor but not in the PHB neuron suggests that EGL-5 specifies precursor fate. PMID: 18505863
  6. bar-1 beta-catenin and egl-5 homeobox genes play an important and conserved role in innate immune defense. PMID: 18981407
  7. The C. elegans Hox gene egl-5 is frequired for correct development of the hermaphrodite hindgut and for the response to rectal infection by Microbacterium nematophilum. PMID: 19232338

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Subcellular Location
Nucleus.
Protein Families
Abd-B homeobox family
Database Links

KEGG: cel:CELE_C08C3.1

STRING: 6239.C08C3.1b

UniGene: Cel.19646

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