elav Antibody

1. Ubiquitous Elav has regulatory capacity, since derepressed Elav can stabilize an Elav-responsive sensor. Repression of Elav in non-neural territories is crucial as misexpression here has profoundly adverse consequences. PMID: 27802174
2. Paused Pol II promotes recruitment of ELAV to extended genes in Drosophila. PMID: 25544561
3. The modulation of Hox RNA processing by ELAV serves to adapt the morphogenesis of the CNS to axial level by regulating Hox expression and consequently activating local programmes of neural differentiation. PMID: 24803653
4. Reducing Elav levels significantly suppressed the worniu mutant phenotype. PMID: 23079601
5. RNA immunoprecipitation assays suggest that ELAV directly binds the proximal polyadenylation signals of many target mRNAs PMID: 23019123
6. ELAV/Hu protein-regulated alternative RNA processing is more conserved than anticipated from the alignment of degenerate low-complexity sequences. PMID: 21705751
7. An integral part of ELAV gene-specific regulation involves combinatorial binding to variably spaced short U-rich motifs on an extensive binding site. PMID: 20659015
8. expression in combination with seven-up and prospero identifies progenitor cell types during sense-organ differentiation in the Drosophila antenna PMID: 12606283
9. Chromosome fusions from patterns of polymorphism at the X-linked elav gene were studied. PMID: 12930752
10. ELAV multimerization and binding to multiple AU(4-6) motifs contribute to target RNA recognition and processing in a complex cellular environment PMID: 16107705
11. unexpectedly observed that, in addition to neurons, ELAV is transiently expressed in embryonic glial cells. Furthermore, it is transiently present in the proliferating longitudinal glioblast, and it is transcribed in embryonic neuroblasts. PMID: 17994541
12. The essential elav gene of Drosophila is newly emerged, restricted to dipterans and of retrotransposed origin PMID: 18715504

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KEGG: dme:Dmel_CG4262

STRING: 7227.FBpp0298002

UniGene: Dm.4473