elt-7 Antibody

Code CSB-PA989739XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans elt-7 Polyclonal antibody
Uniprot No.
Target Names
elt-7
Alternative Names
elt-7 antibody; C18G1.2Transcription factor elt-7 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans elt-7 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3'. Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-2 to control normal gene expression and promote normal formation of the intestine. May have a protective role in response to infection by Gram-negative bacteria such as P.aeruginosa.
Gene References into Functions
  1. Genes expressed only in the intestine showed 3 distinguishable classes of response to different mutant backgrounds. For one class, transcript levels increased upon loss of ELT-2 but decreased upon further loss of ELT-7, suggesting that ELT-7 actually overcompensates for the loss of ELT-2. Appropriately expressed ELT-7 is able to replace all other core GATA factors in the C. elegans endoderm. PMID: 29360433
  2. brief expression of a single transcription factor, the ELT-7 GATA factor, can convert the identity of fully differentiated, highly specialized non-endodermal cells of the pharynx into fully differentiated intestinal cells in intact larvae and adult Caenorhabditis elegans. PMID: 24257624
  3. Both ELT-2 and ELT-7 are important for survival of C. elegans exposed to P. aeruginosa. PMID: 21168435
  4. ELT-7 profoundly synergizes with ELT-2 to create a transcriptional switch essential for gut cell differentiation. PMID: 20807527
Subcellular Location
Nucleus.
Database Links

KEGG: cel:CELE_C18G1.2

STRING: 6239.C18G1.2a

UniGene: Cel.4704

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