emc Antibody

Code CSB-PA322441XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) emc Polyclonal antibody
Uniprot No.
Target Names
emc
Alternative Names
emc antibody; CG1007Protein extra-macrochaetae antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) emc protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Participates in sensory organ patterning by antagonizing the neurogenic activity of the Achaete-scute complex (AS-C). It lacks a basic DNA-binding domain but is able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. May sequester proneural proteins in complexes inefficient for DNA interaction. EMC also affects vein differentiation. Inhibits the activity of AS-C proteins by forming an non-DNA binding heterodimer.
Gene References into Functions
  1. Extramacrochaetae functions in dorsal-ventral patterning of Drosophila imaginal discs. PMID: 25715400
  2. Hh drives and Emc impedes the progression of the furrow across the developing retina. PMID: 24406336
  3. argue that the role emc, h and sr in development of the flight apparatus preceded their activities for macrochaete patterning PMID: 24384389
  4. The role of Emc in eye development is to impose order on the retina by regulating the activity of the Hedgehog and Wingless signaling pathways. PMID: 23536565
  5. These findings question whether hairy is an important regulator of the progression of retinal differentiation in Drosophila, alone or redundantly with extramacrochaete. PMID: 23118874
  6. emc lies downstream of fs(1)K10, gurken and EGFR in the Grk/EGFR signalling pathway and it participates in controlling Broad-Complex expression at late stages of oogenesis. PMID: 16026970
  7. Results show that extramacrochaetae is required for multiple aspects of eye development that depend on Notch signaling, including morphogenetic furrow progression, differentiation of R4, R7 and cone cell types, and rotation of ommatidial clusters. PMID: 19118542

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Subcellular Location
Nucleus.
Database Links

KEGG: dme:Dmel_CG1007

STRING: 7227.FBpp0072477

UniGene: Dm.2147

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