ena Antibody

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Code	CSB-PA851514XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) ena Polyclonal antibody

Uniprot No.

Q8T4F7

Target Names

ena

Alternative Names

ena antibody; enb antibody; CG15112 antibody; Protein enabled antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) ena protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Functions, together with Abl, trio and fra, in a complex signaling network that regulates axon guidance at the CNS midline. Required in part for robo-mediated repulsive axon guidance. May be involved in lamellipodial dynamics.

Gene References into Functions

The Abl tyrosine kinase signaling network controls cell migration, epithelial organization, axon patterning and other aspects of development. Abl suppresses the actin-regulatory factor Enabled, and we find that Abl also acts through the GEF Trio to stimulate the signaling activity of Rac GTPase. PMID: 28087633
Abl/Ena signaling controls the subcellular architecture of the Golgi complex in Drosophila photoreceptor neurons through its regulation of the Golgi-associated actin cytoskeleton. PMID: 25103244
the activities of Ena/VASP and the WAVE regulatory complex are intimately linked to ensure optimal control of actin polymerization during cell migration and development PMID: 25203209
Ena is both sufficient and necessary to account for miR-8-mediated regulation of subsynaptic reticulum architecture. PMID: 24718988
Ena regulates force balance in the somatic gonadal precursors by sequestering DE-cad, leading to the morphogenetic movement required for gonad compaction. PMID: 23300733
Canoe (Cno) and Pyd are required for proper Ena localization during dorsal closure, and strong genetic interactions suggest that Cno, Pyd, and Ena act together in regulating or anchoring the actin cytoskeleton during dorsal closure PMID: 21508316
Ena localises to regions of actin dynamics within migrating haemocytes, stimulates lamellipodial dynamics and positively regulates the number and length of filopodia. PMID: 21045209
In abl mutants, Enabled accumulates ectopically at the apical cortex where excess actin is observed, suggesting that Abl regulates Ena's subcellular localization. PMID: 14676307
Ena/VASP, when not inhibited by the Abl pathway, can bind kinesin heavy chain and reduce its transport activity in axons PMID: 15975902
Enabled (Ena), a substrate for Abl, promotes the formation of both dendritic branches and actin-rich spine-like protrusions of dendritic arborization neurons, an effect opposite to that of Abl PMID: 16003769
Ena modulates filopodial number and length, thus influencing the speed of epithelial zippering and the ability of cells to match with correct neighbors in embryonic morphogenesis. PMID: 17507404
Drosophila enabled/vasodilator stimulated phosphoprotein (Ena/VASP) proteins are candidates for driving cytoskeleton modulation under the membrane. PMID: 18378777
Enabled and Capping actin regulator proteins shape oogenesis. PMID: 19576200

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Subcellular Location

Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Note=Expressed at the leading edge of lamellipodia. Colocalizes with chic at the periphery of cells.

Protein Families

Ena/VASP family

Tissue Specificity

Expressed in axons of the embryonic nervous system.

Database Links

KEGG: dme:Dmel_CG15112

STRING: 7227.FBpp0113115

UniGene: Dm.14700

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ena Antibody

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