nfo Antibody

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Code	CSB-PA363838XA01ENV
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Target Background

Product Details

Full Product Name

Rabbit anti-Escherichia coli (strain K12) nfo Polyclonal antibody

Uniprot No.

P0A6C1

Target Names

nfo

Alternative Names

nfo antibody; b2159 antibody; JW2146Endonuclease 4 antibody; EC 3.1.21.2 antibody; Endodeoxyribonuclease IV antibody; Endonuclease IV antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli (strain K12)

Immunogen

Recombinant Escherichia coli (strain K12) nfo protein

Immunogen Species

Escherichia coli (strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.

Gene References into Functions

Novel Nfo substrates alpha-2'-deoxyadenosine and alpha-thymidine play an important role in counteracting oxidative DNA base damage. PMID: 15568813
analysis of the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV PMID: 17242363
Biochemical, mutational & crystallographic characterization reveal a 3-metal ion mechanism for damage binding and incision; DNA-free and DNA-substrate complex structures capture substrate stabilization by Arg37 and show a distorted Zn3 ligand arrangement. PMID: 18408731

Protein Families

AP endonuclease 2 family

Database Links

KEGG: ecj:JW2146

STRING: 316385.ECDH10B_2316

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Service

Phage Display Service

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Protein Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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nfo Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background