nei Antibody

Datasheet

Code	CSB-PA343478XA01ENV
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Target Background

Product Details

Full Product Name

Rabbit anti-Escherichia coli (strain K12) nei Polyclonal antibody

Uniprot No.

P50465

Target Names

nei

Alternative Names

nei antibody; b0714 antibody; JW0704Endonuclease 8 antibody; DNA glycosylase/AP lyase Nei antibody; EC 3.2.2.- antibody; EC 4.2.99.18 antibody; DNA-(apurinic or apyrimidinic site) lyase Nei antibody; Endonuclease VIII antibody

Raised in

Rabbit

Species Reactivity

Escherichia coli (strain K12)

Immunogen

Recombinant Escherichia coli (strain K12) nei protein

Immunogen Species

Escherichia coli (strain K12)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Acts on DNA bubble and 3'-fork structures, suggesting a role in replication-associated DNA repair. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.

Gene References into Functions

A study of conformational changes in the Nei molecule when the enzyme binds normal DNA, damaged but uncleavable DNA, and several cleavable damaged DNA substrates. PMID: 23000248
Endonuclease VIII does not protect E.coli against possible mutations attributable to formamidopyrimidine lesions. PMID: 15944451
The structure of the uncomplexed Nei shows a significant conformational change compared with the Nei structure in its complex with DNA, reflecting a approximately 50 degrees rotation of the two main domains of the enzyme. PMID: 16145054
Nei base excision repair enzyme is critical for the recognition and repair of the spiroiminodihydantoin lesion in bacterial cell lines PMID: 16167829

Protein Families

FPG family

Database Links

KEGG: ecj:JW0704

STRING: 316385.ECDH10B_0781

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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nei Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background