nei1 Antibody

Code CSB-PA190618XA01FSG
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Product Details

Full Product Name
Rabbit anti-Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) nei1 Polyclonal antibody
Uniprot No.
Target Names
nei1
Alternative Names
nei1 antibody; nei2 antibody; Rv2464c antibody; MTV008.20cEndonuclease 8 1 antibody; DNA glycosylase/AP lyase Nei 1 antibody; EC 3.2.2.- antibody; DNA-(apurinic or apyrimidinic site) lyase Nei 1 antibody; EC 4.2.99.18 antibody; Endonuclease VIII 1 antibody
Raised in
Rabbit
Species Reactivity
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Immunogen
Recombinant Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) nei1 protein
Immunogen Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. DNA glycosylase that recognizes and removes damaged pyrimidines. Excises Tg:A (thymine glycol, prefers 5R isomers), Tg:G, 5,6-dihydrouracil:G base pairs and urea:A, also excises oxidized purine derivatives guanidinohydantoin:C and spiroiminodihydantoin:C. Poorly cleaves dsDNA with uracil substitutions, thus also acting as a weak uracil-DNA glycosylase. Acts on DNA bubble and 3'-fork structures, suggesting a role in replication-associated DNA repair. Activity on 7,8-dihydro-8-oxoguanine (8-oxoG) is debated; a report shows weak activity, whereas another shows none. Has AP (apurinic/apyrimidinic) activity and introduces nicks in dsDNA strand, inefficiently cleaves ssDNA with AP sites and uracil. Probably cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Cleaves ssDNA containing an AP site. Complements an E.coli fpg mutY but not nei nth double mutant.
Protein Families
FPG family
Database Links

KEGG: mtu:Rv2464c

STRING: 83332.Rv2464c

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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