Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ENDOV Polyclonal antibody

Uniprot No.

Q8N8Q3

Target Names

ENDOV

Alternative Names

ENDOVEndonuclease V antibody; hEndoV antibody; EC 3.1.26.- antibody; Inosine-specific endoribonuclease antibody

Raised in

Rabbit

Species Reactivity

Homo sapiens (Human)

Immunogen

Recombinant Homo sapiens (Human) ENDOV protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing (Probable). Binds branched DNA structures.; Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Cleaves tRNAs containing inosine.; Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Cleaves tRNAs containing inosine.

Gene References into Functions

hEndoV is redistributed to stress granules as a strategy to create a local environment low in ATP to permit hEndoV activity. PMID: 27573237
Inosine-specific ribonuclease activity of natural variants of human endonuclease V PMID: 27800608
ENDOV was significantly associated with schizophrenia. PMID: 25053281
Human EndoV appears inactive on DNA, but has been shown to incise various RNA substrates containing inosine. [review] PMID: 25824682
This previously unknown RNA incision activity may suggest a role for endonuclease V in normal RNA metabolism. PMID: 23912683
hEndoV controls the fate of inosine-containing RNA in humans. PMID: 23912718
ENDOV is localized in the cytoplasm and nucleoli of human cells. PMID: 23139746
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20819778

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Subcellular Location

[Isoform 1]: Cytoplasm. Nucleus, nucleolus. Cytoplasm, Stress granule.; [Isoform 6]: Cytoplasm. Nucleus, nucleolus. Cytoplasm, Stress granule.; [Isoform 7]: Cytoplasm. Nucleus, nucleolus. Cytoplasm, Stress granule.

Protein Families

Endonuclease V family

Database Links

HGNC: 26640

KEGG: hsa:284131

STRING: 9606.ENSP00000429190

UniGene: Hs.389678

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ENDOV Antibody

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