env Antibody

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Code	CSB-PA319877XA01MIT
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Target Background

Product Details

Full Product Name

Rabbit anti-Mouse mammary tumor virus (strain BR6) (MMTV) env Polyclonal antibody

Uniprot No.

P10259

Target Names

env

Alternative Names

envEnvelope glycoprotein gp70 antibody; Env polyprotein) [Cleaved into: Surface protein antibody; SU antibody; Glycoprotein 52 antibody; gp52); Transmembrane protein antibody; TM antibody; Glycoprotein 36 antibody; gp36)] antibody

Raised in

Rabbit

Species Reactivity

Mouse mammary tumor virus (strain BR6) (MMTV)

Immunogen

Recombinant Mouse mammary tumor virus (strain BR6) (MMTV) env protein

Immunogen Species

Mouse mammary tumor virus (strain BR6) (MMTV)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

The surface protein (SU) attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane.; The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.

Gene References into Functions

Data suggest a potential mechanism for the initiation of breast cancer and identify MMTV Env and ITAM-containing proteins in human breast tumors as probable oncoproteins. PMID: 15684322
the MMTV Env protein participates in mammary epithelial cell transformation in vivo and this requires a functional immunoreceptor tyrosine activation motif in the envelope protein PMID: 16940512

Subcellular Location

[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.; [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein.

Database Links

KEGG: vg:1491862

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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env Antibody

Product Details

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Customer Reviews and Q&A

Target Background