e(y)2 Antibody

Code CSB-PA894756XA01DLU
Size Enquire
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) e(y)2 Polyclonal antibody
Uniprot No.
Target Names
e(y)2
Alternative Names
e(y)2 antibody; ENY2 antibody; CG15191Enhancer of yellow 2 transcription factor antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) e(y)2 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes. The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Involved in transcription elongation by recruiting the THO complex onto nascent mRNA. The AMEX complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). AMEX participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Recruited to the su(Hw) insulators via its interaction with su(Hw) and participates in the barrier activity of such insulators. In contrast, it does not participate in the enhancer-blocking activity of the su(Hw) insulators.
Gene References into Functions
  1. ENY2 protein forms a part of the THO complex of Drosophila melanogaster. PMID: 20714859
  2. 368-bp core of E(y)2 insulator is sufficient for blocking Polycomb response element-mediated silencing. PMID: 20082086
  3. The e(y)2 gene derived as a result of retroposition of the e(y)2b gene during Drosophila evolution. PMID: 16314324
  4. The e(y)2b gene is a paralogue of the e(y)2 gene. PMID: 16314324
  5. 3 additional subunits of TFTC/STAGA (ATXN7L3, USP22, & ENY2) help form the deubiquitination module. This module is an enhancer of position effect variegation in Drosophila. ATXN7L3 and USP22. PMID: 18206972
  6. E(y)2, the novel component of SAGA/TFTC complex in eucaryotes participates in export of mRNP from nucleus and couples transcription with nuclear pore PMID: 19425494
  7. E(y)2 and Xmas-2 together with SAGA/TFTC functioned in the anchoring of a subset of transcription sites to the NPCs to achieve efficient transcription and mRNA export. PMID: 19947544
  8. ENY2 in Drosophila is also stably associated with THO, the complex involved in mRNP biogenesis PMID: 20048002

Show More

Hide All

Subcellular Location
Nucleus, nucleoplasm. Cytoplasm.
Protein Families
ENY2 family
Tissue Specificity
Ubiquitous.
Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1