Code | CSB-PA007840XA01SVG |
Size | US$299 |
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The procedure for generating polyclonal antibodies against SUP45 involves repetitive immunizations of a rabbit with recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SUP45 protein (26-262aa). Upon reaching a sufficient antibody titer, the rabbit undergoes bleeding, and the serum-derived antibodies are purified through affinity chromatography. Two applications ELISA and WB have been used in assays to test for the specificity of this SUP45 antibody. The SUP45 antibody shows specific reactivity towards Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SUP45 protein.
The SUP45 is a vital component of the translation termination machinery in yeast. Its primary function lies in facilitating the accurate and timely termination of protein synthesis. Acting as a translation release factor, SUP45 catalyzes the hydrolysis of the ester bond between the polypeptide chain and the tRNA molecule, ensuring the proper release of the newly synthesized protein from the ribosome when a stop codon is encountered. SUP45 also contributes to quality control mechanisms by recognizing and responding to premature termination events, thereby preventing the synthesis of incomplete or faulty proteins.
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KEGG: sce:YBR143C
STRING: 4932.YBR143C