esc Antibody

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Code	CSB-PA635523XA01DLU
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Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) esc Polyclonal antibody

Uniprot No.

Q24338

Target Names

esc

Alternative Names

esc antibody; CG14941Polycomb protein esc antibody; Protein extra sex combs antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) esc protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required.

Gene References into Functions

The ESC is a key component of the Polycomb repressive complex 2 (PRC2), which mediates H3K27me3 modification. PMID: 21700228
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. PMID: 12408863
We purified an ESC-E(Z) complex from Drosophila embryos and found four major subunits: ESC, E(Z), NURF-55, and the PcG repressor, SU(Z)12. A recombinant complex reconstituted from these four subunits methylates lysine-27 of histone H3. PMID: 12408864
ESC and E(Z) are present in multiple distinct complexes that undergo dynamic changes during development PMID: 12533794
Here, we show that Sex combs extra (Sce) encodes Ring and that Sce/Ring function is critically required for PcG silencing. PMID: 12963114
extreme Polycomb embryonic phenotype due to the lack of maternal and zygotic Sex combs extra can be rescued by ectopic expression of Ring/Sex combs extra PMID: 15147763
Thus, stability and perhaps assembly of larger ESC complexes may depend on ESC phosphorylation. PMID: 15896722
esc and E(Pc) mutants enhance homologous recombination by modulating the histone acetylation status of histone H4 at the double-strand break PMID: 16452150
one of the roles of ESC (and ESCL and EED) in Polycomb repressive complex 2 complexes is to enable Enhancer of zeste to utilize histone H3 as a substrate by physically linking enzyme and substrate PMID: 17210640
A Pcl-PSC2 complex is the histone methyltransferase that generates the high levels of histone3-lysine27 trimethylation in Polycomb target genes that are needed to maintain a Polycomb-repressed chromatin state. PMID: 17762866
These data thus indicate that ESC and ESCL play similar if not identical functions in E(Z) complexes in vivo. PMID: 18048023
analysis of the roles of ESC and ESCL in Polycomb Group mechanisms PMID: 18276122

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Subcellular Location

Nucleus.

Protein Families

WD repeat ESC family

Tissue Specificity

Widely expressed.

Database Links

KEGG: dme:Dmel_CG14941

STRING: 7227.FBpp0079907

UniGene: Dm.1948

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