esc Antibody

Code CSB-PA631647XA01DMP
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Product Details

Full Product Name
Rabbit anti-Drosophila virilis (Fruit fly) esc Polyclonal antibody
Uniprot No.
Target Names
esc
Alternative Names
escPolycomb protein esc antibody; Protein extra sex combs antibody
Raised in
Rabbit
Species Reactivity
Drosophila virilis (Fruit fly)
Immunogen
Recombinant Drosophila virilis (Fruit fly) esc protein
Immunogen Species
Drosophila virilis (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Polycomb group (PcG) protein. In contrast to other PcG protein, it is specifically required during the first 6 hours of embryogenesis to establish PcG silencing. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via a methylation of histones, rendering chromatin heritably changed in its expressibility. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3. The Esc/E(z) complex is necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.
Subcellular Location
Nucleus.
Protein Families
WD repeat ESC family
CUSABIO guaranteed quality
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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