esco2 Antibody

Code CSB-PA716324XA01DIL
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Product Details

Full Product Name Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) esco2 Polyclonal antibody
Uniprot No. Q5SPR8
Target Names esco2
Alternative Names esco2 antibody; si:dkey-217m5.6 antibody; zgc:111795N-acetyltransferase ESCO2 antibody; EC 2.3.1.- antibody; Establishment of cohesion 1 homolog 2 antibody; ECO1 homolog 2 antibody
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) esco2 protein
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

Function
(From Uniprot)
Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. Essential for early development.
Gene References into Functions
  1. esco2 is upregulated during fin regeneration. esco2 knockdown adversely affects tissue and bone growth in regenerating fins-consistent with role in skeletal morphogenesis. knockdown diminishes cx43 expression which is required for cell-cell communication PMID: 26434741
  2. although many cells required Esco2 to establish cohesion, 10-20% of cells had only weakened cohesion in the absence of Esco2, suggesting that compensatory cohesion mechanisms exist in these cells that undergo a normal mitotic division. PMID: 26044958
  3. Esco2 depleted zebrafish embryos exhibit features that resemble Roberts Syndrome, including mitotic defects, craniofacial abnormalities and limb truncations. PMID: 21637801
Subcellular Location Nucleus. Chromosome.
Protein Families Acetyltransferase family, ECO subfamily
Database Links

KEGG: dre:445395

STRING: 7955.ENSDARP00000002535

UniGene: Dr.75608

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