esiB Antibody

Code CSB-PA126743XA01FQR
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Product Details

Full Product Name
Rabbit anti-Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) esiB Polyclonal antibody
Uniprot No.
Target Names
esiB
Alternative Names
esiB antibody; c5321Secretory immunoglobulin A-binding protein EsiB antibody
Raised in
Rabbit
Species Reactivity
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Immunogen
Recombinant Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) esiB protein
Immunogen Species
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Upon host (human neutrophil) infection interferes with productive FCAR signaling, inhibiting secreted IgA (SIgA) effector functions and probably avoiding neutrophil activation. Inhibits the SIgA-mediated oxidative burst by neutrophils, decreases generation of ROS (reactive oxygen species) by neutrophils and reduces chemotaxis by neutrophils, all of which are SIgA effector functions used to stimulate the immune response. Does not block SIgA-binding to its receptor (FCAR) on neutrophils, but it decreases SIgA-stimulated phosphorylation of cytoplasmic proteins, including phospholipase C-gamma and MAP kinases, all actions that may be advantageous to the pathogen.
Subcellular Location
Cell surface.
Database Links

KEGG: ecc:c5321

STRING: 199310.c5321

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