ESP1 Antibody

Datasheet

Code	CSB-PA939208XA01DOA
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) ESP1 Polyclonal antibody

Uniprot No.

Q5IBC5

Target Names

ESP1

Alternative Names

ESP1 antibody; AESP antibody; ESP antibody; RSW4 antibody; At4g22970 antibody; F7H19.150Separase antibody; EC 3.4.22.49 antibody; Protein EXTRA SPINDLE POLES antibody; AtESP antibody; Protein RADIALLY SWOLLEN 4 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana ESP1 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Cleaves SYN1, releasing sister chromatid cohesion. Required for the release of cohesin at anaphase I and anaphase II, whereas the release of cohesin during diplotene and diakinesis occurs in a separase-independent process. Essential for embryo and endosperm development. May play a role in centromeric heterochromatin structure/formation during early meiosis, non-homologous centromere association and radial microtubule system (RMS) formation. May regulate the mitosis-specific cyclin CYCB1-1.

Gene References into Functions

the N-terminal non-catalytic domain of separase binds to the C-terminal tail domain of three homologs of the centromeric protein CENP-E Kinesin 7. PMID: 27219063
The crystal structure of the Arabidopsis thaliana ESP protein has been reported. PMID: 27498030
Data indicate that caspase-related protease separase (extra spindle poles [ESP]) colocalizes with microtubules and RabA2a, and facilitates polar targeting of the auxin efflux carrier PIN-formed2 (PIN2) to the rootward side of the root cortex cell. PMID: 23898031
AESP plays an essential role in embryo development and is required for the removal of cohesin from meiotic chromosomes. [AESP] PMID: 16582011
It was shown that meiotic expression of ESP blocked the removal of cohesin during meiosis, resulted in alterations in centromere association, disrupted the radial microtubule system, and affected the establishment of nuclear cytoplasmic domains. PMID: 19592426

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Tissue Specificity

Expressed in roots, stems, leaves and buds.

Database Links

KEGG: ath:AT4G22970

STRING: 3702.AT4G22970.1

UniGene: At.32480

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Oct4 -- The Gatekeeper of Pluripotency of Embryonic Stem Cells Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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