esxO Antibody

Code CSB-PA967956XA01FSG
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Product Details

Full Product Name
Rabbit anti-Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) esxO Polyclonal antibody
Uniprot No.
Target Names
esxO
Alternative Names
esxO antibody; Rv2346c antibody; MTCY98.15cESAT-6-like protein EsxO antibody
Raised in
Rabbit
Species Reactivity
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Immunogen
Recombinant Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) esxO protein
Immunogen Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays an important role in mycobacterial pathogenesis in the context of innate immunity. Aids host cell invasion and intracellular bacillary persistence. Increases host oxidative stress response, leading to genomic instability and decrease in macrophage viability. Also induces autophagy and modulates the immune function of macrophages.
Gene References into Functions
  1. Mycobacterium tuberculosis Rv2346c dampens antibacterial effector functions by inducing oxidative stress mediated genomic instability in infected macrophages. PMID: 26786654
Subcellular Location
Secreted.
Protein Families
WXG100 family, ESAT-6 subfamily
Database Links

KEGG: mtu:Rv2346c

STRING: 83332.Rv2346c

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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