ets-5 Antibody

Code CSB-PA287444XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans ets-5 Polyclonal antibody
Uniprot No.
Target Names
ets-5
Alternative Names
ets-5 antibody; C42D8.4ETS domain-containing transcription factor ets-5 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans ets-5 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcription factor that plays a role in the differentiation and function of the CO(2)- and O(2)-sensing BAG neurons. The BAG neurons are required for the behavioral avoidance of environmental CO(2) and the sensing of decreased O(2) levels. Promotes the expression of genes that play a role in CO(2)- and O(2)-sensing and in egg-laying in the BAG neurons. Positively regulates the transcription of the receptor-type guanylate cyclase gcy-9, which is a critical component of the CO(2) transduction pathway, in the BAG neurons. May mediate transcriptional activation by binding to the motif 5'-ACTTCCG-3'. Acts in the BAG and ASG neurons to regulate intestinal fat levels and to promote exploratory behavior, possibly by regulating neuropeptidergic signaling.
Gene References into Functions
  1. Expression of a single ETS-5 target gene, gcy-9, which encodes a receptor-type guanylate cyclase, is sufficient to bypass a requirement for ets-5 in CO(2)-detection and transforms neurons into CO(2)-sensing neurons PMID: 22479504
Subcellular Location
Nucleus.
Protein Families
ETS family
Tissue Specificity
Expressed in a subset of head neurons, including the BAG sensory neurons, the AWA amphid neurons and the ASG sensory neurons.
Database Links

STRING: 6239.C42D8.4

UniGene: Cel.11199

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