EXO5 Antibody

Code CSB-PA863995ZA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) EXO5 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
EXO5 antibody; C1orf176 antibody; DEM1 antibody; Exonuclease V antibody; Exo V antibody; hExo5 antibody; EC 3.1.-.- antibody; Defects in morphology protein 1 homolog antibody
Raised in
Species Reactivity
Homo sapiens
Recombinant Homo sapiens EXO5 protein
Immunogen Species
Homo sapiens (Human)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity.
Gene References into Functions
  1. The human homolog (C1orf176; EXO5) that functions in the repair of nuclear DNA damage. PMID: 23095756
Subcellular Location
Nucleus. Cytoplasm, cytosol. Note=Localizes to repair foci in response to DNA damage.
Protein Families
EXO5 family
Database Links

HGNC: 26115

KEGG: hsa:64789

STRING: 9606.ENSP00000296380

UniGene: Hs.59584

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