ex Antibody

Datasheet

Code	CSB-PA285316XA01DLU
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) ex Polyclonal antibody

Uniprot No.

Q07436

Target Names

Alternative Names

ex antibody; CG4114Protein expanded antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) ex protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Activates the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Ex acts synergistically along with Mer and Kibra to regulate the Hippo signaling pathway. Involved in the control of cell proliferation in imaginal disks. May bind to certain proteins of signal transduction pathways by interaction with their SH3 domains. Required for apical localization of Schip1.

Gene References into Functions

results show that Zyxin is a functional antagonist of Expanded in growth control PMID: 25728696
The Ex-regulatory domain of Crb maps to the juxtamembrane FERM-binding motif (JM), a cytoskeletal interaction domain distinct from the PDZ-binding motif (PBM) through which Crb binds polarity factors. PMID: 20362445
Expanded is required for proliferation arrest and apoptosis in developing imaginal discs. Our genetic and biochemical data place Merlin and Expanded upstream of Hippo and identify a pathway through which they act as tumour-suppressor genes. PMID: 16341207
The tumor suppressor expanded (ex)controls proliferation by regulating the abundance, localization, and turnover of cell-surface receptors. PMID: 16581517
Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways. PMID: 17359963
Data show that expanded genes are dispensable in germline cells for their proliferation control and it appears that expanded acts from the somatic support cells surrounding the germline to restrict spermatogonial amplification. PMID: 18095349
new model whereby Expanded functions downstream of Warts, in concert with 14-3-3 proteins to sequester Yorkie in the cytoplasm, inhibiting growth activity of the Hippo pathway PMID: 19289086

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Subcellular Location

Apical cell membrane. Note=Apical surface of disk cells.

Database Links

KEGG: dme:Dmel_CG4114

STRING: 7227.FBpp0077719

UniGene: Dm.247

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