rib-2 Antibody

Code CSB-PA007900XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans rib-2 Polyclonal antibody
Uniprot No.
Target Names
rib-2
Alternative Names
rib-2 antibody; K01G5.6Exostosin-2 homolog antibody; EC 2.4.1.223 antibody; EC 2.4.1.224 antibody; EC 2.4.1.225 antibody; Glucuronyl-galactosyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase antibody; GlcNAc transferase I antibody; GlcNAcT-I antibody; Glucuronyl-galactosyl-proteoglycan/Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase antibody; GlcAT-II antibody; GlcNAc transferase II antibody; GlcNAcT-II antibody; Glucuronyl transferase II antibody; Multiple exostoses homolog 2 antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans rib-2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Glycosyltransferase required for the biosynthesis of heparan sulfate. Initiates heparan sulfate synthesis by transferring GlcNAc to the (GlcA-Gal-Gal-Xyl-)Ser core linker (GlcNAcT-I activity). In association with rib-1, is also responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains (GlcNAcT-II and GlcAT-II activities). Required for normal ventral epidermal enclosure during the early stages of embryonic development. In addition, involved in the elongation of the pharyngeal isthmus during the later stages of embryonic development. Involved in the directed migration of hermaphrodite-specific neurons.
Gene References into Functions
  1. results indicate that rib-2 is essential for embryonic development and heparan sulfate biosynthesis in C. elegans PMID: 12565862
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein.
Protein Families
Glycosyltransferase 47 family
Database Links

KEGG: cel:CELE_K01G5.6

STRING: 6239.K01G5.6

UniGene: Cel.17904

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