eya Antibody

1. This study showed that the eya2 mutants with disrupted vision showed normal mating effects on sleep. PMID: 28851647
2. speculate that Eya's tyrosine phosphatase activity, although non-essential, confers robustness to RDGN output PMID: 29108015
3. Uncover a novel role for Eya and So in promoting cell cycle exit in the retinal second mitotic wave (SMW), a synchronized, terminal cell division that occurs several hours after passage of the furrow. We show that Combgap (Cg), a zinc-finger transcription factor, antagonizes Eya-So function in the SMW. PMID: 28619818
4. By removing gene function in differentiating cells, the study shows that eya is dispensable for larval photoreceptor differentiation, but is required for differentiation during pupal development. PMID: 27257739
5. our data provide new insight into the cytoplasmic phosphotyrosine signaling networks that operate during photoreceptor axon guidance and suggest specific points of interaction with Eya. PMID: 27194748
6. In this report we explore the mechanisms by which eya expression is spatially and temporally governed in the developing eye. We demonstrate that multiple cis-regulatory elements function cooperatively to control eya transcription and that spacing between a pair of enhancer elements is important for maintaining correct gene expression PMID: 27930646
7. A primary function of Eya during Drosophila eye development is as a transcriptional coactivator. PMID: 26980695
8. Data show that eyes absent protein (Eya) is required in late progenitors to promote eye formation, and that failure to induce the target gene atonal and consequent lack of neuron formation. PMID: 25980363
9. Drosophila eya is required for normal cone and pigment cell development. PMID: 25057928
10. Cas and Eya exhibit complementary expression patterns in egg chambers; Cas is restricted to polar and stalk cells from which Eya is excluded. Eya inhibits Cas expression; suppression of Eya is necessary for polar and stalk cell specification. PMID: 23610413
11. in contrast to ectopic eye formation, MAPK-mediated phosphorylation of Eya on S402 and S407 does not play a role in normal development. PMID: 23251383
12. data provide the first in vivo demonstration for the immune function of EYA and point to their conserved immune function in response to endogenous DNA, throughout evolution PMID: 22916150
13. Confocal images of Drosophila third instar eye-antennal discs indicate a subpopulation of retinal progenitor and precursor cells survives within the eya2 mutant eye field. PMID: 23222441
14. the EGFR pathway is known to regulate the activity of Eya through phosphorylation via MAPK; findings suggest that this pathway is also used to influence eya transcriptional levels PMID: 19884307
15. Data show that the gene eyes absent (eya) is a key repressor of polar cell fate. PMID: 12403709
16. Data show that the retinal determination gene eyes absent (eya) is the crucial link between the Hedgehog signaling pathway and photoreceptor differentiation. PMID: 12756186
17. This protein has a somatic role in spermatocyte development. PMID: 12781687
18. Our data suggest that EYA requires homo- and heterotypic interactions and RAS/MAPK signaling responsiveness to ensure context-appropriate RD gene network activity. PMID: 12917324
19. Eyes absent is the prototype for a class of protein tyrosine phosphatases that use a nucleophilic aspartic acid in a metal-dependent reaction; the phosphatase activity of Eyes absent contributes to its ability to induce eye formation in Drosophila PMID: 14628052
20. Experiments performed in cultured Drosophila cells and in vitro indicate that Eyes absent has intrinsic protein tyrosine phosphatase activity and can autocatalytically dephosphorylate itself PMID: 14628053
21. dachshund and eyes absent genes have roles in BMP signaling, axon pathfinding and neuronal specification PMID: 15525669
22. EYA and SO may influence cell proliferation through transcriptional regulation of stg. PMID: 17714699
23. in addition to its role as a transcription factor, Eya functions as a cytoplasmic protein tyrosine phosphatase PMID: 19217428
24. analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development PMID: 19217429

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KEGG: dme:Dmel_CG9554

STRING: 7227.FBpp0078964

UniGene: Dm.5293