F Antibody

Datasheet
Code CSB-PA319265ZA01HPW

Product Details

Full Product Name Rabbit anti-Human respiratory syncytial virus A (strain RSS-2) F Polyclonal antibody
Uniprot No. P11209
Target Names F
Alternative Names Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2'; Interchain peptide; Fusion glycoprotein F2; Fusion glycoprotein F1], F
Raised in Rabbit
Species Reactivity Human respiratory syncytial virus A
Immunogen Recombinant Human respiratory syncytial virus A Fusion glycoprotein F0 (F), partial (27-529AA)
Immunogen Species Human respiratory syncytial virus A (strain RSS-2)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Made-to-order
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Target Data

Function During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participate in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.
Subcellular Location Virion membrane, Single-pass type I membrane protein, Host cell membrane, Single-pass membrane protein
Protein Families Paramyxoviruses fusion glycoprotein family

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