FAN1 Antibody

Datasheet
Code CSB-PA638065XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q1LWH4
Delivery Make-to-order
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) FAN1 protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (Myotubularin-related protein 15) fan1 mtmr15 si:ch211-163b1.2 si:ch211-201b11.2
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Protocols ELISA Protocol
Gene Names fan1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL. Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap. Also has endonuclease activity toward 5'-flaps.
Subcellular Location Nucleus
Protein Families FAN1 family
Database Links

KEGG: dre:565458

STRING: 7955.ENSDARP00000084286

UniGene: Dr.35714

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