ft Antibody

1. Vamana associates with the Dachsous intracellular domain and with a region of the Fat intracellular domain that is essential for controlling Hippo signaling and levels of Dachs. PMID: 27746048
2. App promotes drosophila growth via the Hippo pathway by palmitoylation of Fat protein. PMID: 28031421
3. Study shows Drosophila Ft functions in mitochondria to directly regulate mitochondrial electron transport chain integrity and promote oxidative phosphorylation. PMID: 25215488
4. Ft's roles in planar cell polarity signaling and tissue size control PMID: 23667559
5. Ft and Crb act as sensors to drive cell orientation during intercalary regeneration and control Yki levels to ensure a proper balance between proliferation and cell reorientation. PMID: 23903186
6. The human Fat homolog FAT4 lacks the ability to transduce Hippo signaling in Drosophila, but can transduce Drosophila planar cell polarity signaling. PMID: 23318637
7. cell shape, junctional localization and cytoskeletal planar polarity in the Drosophila embryo are regulated by a common signal provided by the atypical cadherin Fat PMID: 23250217
8. study shows how the Fat/Dachsous/Four-jointed planar cell polarity pathway controls morphogenesis PMID: 22499807
9. Through epistasis tests, the requirement for Zyx is positioned within the Fat branch of Hippo signaling, downstream of Fat and Dco, and upstream of the Yorkie kinase Warts. PMID: 21666802
10. Fat/Hippo pathway regulates the progress of neural differentiation signaling in the Drosophila optic lobe. PMID: 21671914
11. We posit that Wg propels wing growth at least in part by fueling a wave front of Ft-Ds signaling that propagates vg expression from one cell to the next PMID: 20532238
12. role in growth and planar polarity and relation to dachsous modulated by four-jointed phosphorylation PMID: 20434337
13. Fat plays a role in the polarity and orientation of ommatidia in the Drosophila eye, and is regulated by dachsous protein. PMID: 11893338
14. These data lead us to a model in which fat and Atro act twice in the determination of planar polarity in the eye: first in setting up positional information through the production of a planar polarity diffusible signal, and later in R3 fate determination PMID: 12506006
15. Polarity of Drosophila wing hairs is controlled by two tiers of the planar cell polarity signalling pathway, orcestrated by fat and frizzled PMID: 12540853
16. fat acts in parallel to EGFR pathway in transducing different cell communication signals, and its function is requested downstream of MAPK for a correct rendering of the growth signals converging to the EGFR PMID: 15652705
17. functional relationships among D. melanogaster tumor suppressors and components of a Fat signaling pathway. PMID: 16980976
18. Study reports that the protocadherin Fat acts as an upstream component in the Hippo pathway, Fat is a known tumor-suppressor gene in Drosophila, and fat mutants have severely overgrown imaginal discs. PMID: 16996265
19. data suggest that Fat functions as a cell-surface receptor for the Expanded branch of the conserved Hippo growth control pathway PMID: 16996266
20. Fat modulates Salvador/Warts/Hippo pathway activity by promoting abundance and localization of Expanded protein at the apical membrane of epithelial tissues. PMID: 17045801
21. Fat is subject to a constitutive proteolytic processing, such that most or all cell surface Fat comprises a heterodimer of stably associated N- and C-terminal fragments. PMID: 19574458
22. identification of a conserved cytoplasmic protein, Lowfat (Lft), as a modulator of Fat signaling PMID: 19710173
23. Results provide evidence for a pathway in which Yorkie activity is repressed by direct physical association with three other pathway components: Expanded, Hippo, and Warts. PMID: 19733165

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KEGG: dme:Dmel_CG3352

STRING: 7227.FBpp0077167

UniGene: Dm.293